Was Jesus actively persecuted at any other points during his Ministry and/or adult life?

It's commonly agreed upon that the Ministry of Jesus lasted at least 3 years. However, the plot to arrest Jesus begins only a few days before his crucifixion according to Matthew 26:1-5. Do we know if Jesus was actively persecuted during his Ministry (and/or earlier in his adult life) by command of either the Roman government or the Jewish leaders at any point other than the few days immediately leading up to his crucifixion?