Do some people face setbacks in life because they have digressed from God's purpose, as seen in the case of Jonah?

In the book of Jonah, the prophet is commanded by God to go to Nineveh, but he chooses to flee in the opposite direction. As a result, he faces a storm at sea and is swallowed by a great fish, symbolizing a form of divine intervention or correction. Eventually, he fulfills his mission. Can some of the difficulties or losses that believers experience in life be attributed to them having strayed from the specific purpose or calling God has placed on their lives, similar to Jonah’s situation? - Are there theological or denominational views that support or reject this idea? - How does the New Testament handle this concept, especially in the context of grace and free will? - Are there examples besides Jonah where people faced hardship because of ignoring God’s will?