Theravada perspective on transgender people

What would be the Theravada approach to people who have a transgender experience? As far as I understand it, the mind does not have a gender. So should a Buddhist, out of compassion alone, indulge a transgender person in their request to be regarded as a gender opposite that which they are born; or is this not compassion at all, to indulge one in things which you understand to not be based in reality? Where is the line drawn where one crosses over from being compassionate to being dishonest to oneself and what you have experienced to be true? I know this may be a sensitive subject to some, and I'm not trying to marginalize anyone else's experience of reality; only trying to gain some perspective on how to relate to the world. Thank you