Limits on enduring suffering

As we would all know, the Buddha found/explained that self mortification like extreme fasting is not the correct way to liberation. So is dealing with extreme suffering also not an extreme? If one was in extreme poverty and/or extreme illness would it not be wiser to take the knife? Is there any precedent the Buddha explained in regards to dealing with extreme suffering and/or illness? a level of how much suffering we can or are able to endure? I know there is the story of the monk who took the knife because of extreme illness and the Buddha said he was blameless but he was already a high level attainer (not sure what stage of liberation he was) **EDIT:** wanted to bounty this as the question has not been answered and people seem to misunderstand the question and think it is related to suicide, and tag it as such just because I mentioned about taking the Knife. **The question is about what limits, if any, of suffering we should endure. Is there any precedent about when we should no longer endure suffering because it is too great.** Hypothetically imagining one is homeless, destitute in extreme poverty, starving, no limbs or illnesses akin that cause ones life to be extreme suffering or even extreme mental illness, all family and friends have died of illness or murder. Essentially one has serious negative karma where ones life is full of painful memories and painful present experiences. Is one still supposed to continue to endure such suffering forever. Well until natural death.